Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei.

Synergistic Interaction Between Phenothiazines And Antimicrobial Agents in Burkholderia pseudomallei AUTHORS:

In vitro activity of tigecycline against Burkholderia pseudomallei and Burkholderia thailandensis.

Investigation of the in vitro activity of tigecycline against Burkholderia pseudomallei and Burkholderia thailandensis revealed that the inhibition zone diameters of tigecycline against all isolates were >or=20 mm and that the MIC50 values were 0.5 and 1 microg/ml and the MIC90 values were 2 and 1.5 microg/ml for B. pseudomallei and B. thailandensis, respectively.

In vitro activity of doripenem against Burkholderia pseudomallei.

The MIC(50) and MIC(90) values of doripenem, determined by Etest, for 110 isolates of Burkholderia pseudomallei were 0.5 and 0.75 microg/ml, respectively. There were significant correlations between MICs determined by Etest and MICs determined by agar dilution, MICs determined by Etest and inhibition zone size, and MICs determined by agar dilution and inhibition zone size.

Interaction of Interferon gamma-induced reactive oxygen species with ceftazidime leads to synergistic killing of intracellular Burkholderia pseudomallei.

Burkholderia pseudomallei, a facultative intracellular pathogen, causes severe infections and is inherently refractory to many antibiotics. Previous studies from our group have shown that interferon gamma (IFN-γ) interacts synergistically with the antibiotic ceftazidime to kill bacteria in infected macrophages. The present study aimed to identify the underlying mechanism of that interaction. We...

Loss of Methyltransferase Function and Increased Efflux Activity Leads to Doxycycline Resistance in Burkholderia pseudomallei.

The soil-dwelling bacterium Burkholderia pseudomallei is the causative agent of the potentially fatal disease melioidosis. The lack of a vaccine toward B. pseudomallei means that melioidosis treatment relies on prolonged antibiotic therapy, which can last up to 6 months in duration or longer. Due to intrinsic resistance, few antibiotics are effective against B. pseudomallei The lengthy treatmen...